Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila.
Identifieur interne : 000254 ( Main/Exploration ); précédent : 000253; suivant : 000255Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila.
Auteurs : Joseph M. Schinaman [États-Unis] ; Anil Rana [États-Unis] ; William W. Ja [États-Unis] ; Rebecca I. Clark [Royaume-Uni] ; David W. Walker [États-Unis]Source :
- Scientific reports [ 2045-2322 ] ; 2019.
Descripteurs français
- KwdFr :
- Animal génétiquement modifié (MeSH), Animaux (MeSH), Autophagie (effets des médicaments et des substances chimiques), Autophagie (génétique), Axénie (MeSH), Drosophila (effets des médicaments et des substances chimiques), Drosophila (microbiologie), Drosophila (physiologie), Femelle (MeSH), Homologue de la protéine-1 associée à l'autophagie (génétique), Homéostasie protéique (effets des médicaments et des substances chimiques), Homéostasie protéique (génétique), Interférence par ARN (MeSH), Longévité (effets des médicaments et des substances chimiques), Microbiome gastro-intestinal (effets des médicaments et des substances chimiques), Modèles animaux (MeSH), Muqueuse intestinale (effets des médicaments et des substances chimiques), Muqueuse intestinale (microbiologie), Muqueuse intestinale (métabolisme), Mâle (MeSH), Perméabilité (effets des médicaments et des substances chimiques), Protéines de Drosophila (génétique), Sirolimus (pharmacologie), Techniques de knock-down de gènes (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Autophagie, Drosophila, Homéostasie protéique, Longévité, Microbiome gastro-intestinal, Muqueuse intestinale, Perméabilité.
- génétique : Autophagie, Homologue de la protéine-1 associée à l'autophagie, Homéostasie protéique, Protéines de Drosophila.
- microbiologie : Drosophila, Muqueuse intestinale.
- métabolisme : Muqueuse intestinale.
- pharmacologie : Sirolimus.
- physiologie : Drosophila.
- Animal génétiquement modifié, Animaux, Axénie, Femelle, Interférence par ARN, Modèles animaux, Mâle, Techniques de knock-down de gènes.
English descriptors
- KwdEn :
- Animals (MeSH), Animals, Genetically Modified (MeSH), Autophagy (drug effects), Autophagy (genetics), Autophagy-Related Protein-1 Homolog (genetics), Drosophila (drug effects), Drosophila (microbiology), Drosophila (physiology), Drosophila Proteins (genetics), Female (MeSH), Gastrointestinal Microbiome (drug effects), Gene Knockdown Techniques (MeSH), Germ-Free Life (MeSH), Intestinal Mucosa (drug effects), Intestinal Mucosa (metabolism), Intestinal Mucosa (microbiology), Longevity (drug effects), Male (MeSH), Models, Animal (MeSH), Permeability (drug effects), Proteostasis (drug effects), Proteostasis (genetics), RNA Interference (MeSH), Sirolimus (pharmacology).
- MESH :
- chemical , genetics : Autophagy-Related Protein-1 Homolog, Drosophila Proteins.
- drug effects : Autophagy, Drosophila, Gastrointestinal Microbiome, Intestinal Mucosa, Longevity, Permeability, Proteostasis.
- genetics : Autophagy, Proteostasis.
- metabolism : Intestinal Mucosa.
- microbiology : Drosophila, Intestinal Mucosa.
- chemical , pharmacology : Sirolimus.
- physiology : Drosophila.
- Animals, Animals, Genetically Modified, Female, Gene Knockdown Techniques, Germ-Free Life, Male, Models, Animal, RNA Interference.
Abstract
The FDA approved drug rapamycin can prolong lifespan in diverse species and delay the onset of age-related disease in mammals. However, a number of fundamental questions remain unanswered regarding the mechanisms by which rapamycin modulates age-related pathophysiology and lifespan. Alterations in the gut microbiota can impact host physiology, metabolism and lifespan. While recent studies have shown that rapamycin treatment alters the gut microbiota in aged animals, the causal relationships between rapamycin treatment, microbiota dynamics and aging are not known. Here, using Drosophila as a model organism, we show that rapamycin-mediated alterations in microbiota dynamics in aged flies are associated with improved markers of intestinal and muscle aging. Critically, however, we show that the beneficial effects of rapamycin treatment on tissue aging and lifespan are not dependent upon the microbiota. Indeed, germ-free flies show delayed onset of intestinal barrier dysfunction, improved proteostasis in aged muscles and a significant lifespan extension upon rapamycin treatment. In contrast, genetic inhibition of autophagy impairs the ability of rapamycin to mediate improved gut health and proteostasis during aging. Our results indicate that rapamycin-mediated modulation of the microbiota in aged animals is not causally required to slow tissue and organismal aging.
DOI: 10.1038/s41598-019-44106-5
PubMed: 31127145
PubMed Central: PMC6534571
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila.</title><author><name sortKey="Schinaman, Joseph M" sort="Schinaman, Joseph M" uniqKey="Schinaman J" first="Joseph M" last="Schinaman">Joseph M. Schinaman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rana, Anil" sort="Rana, Anil" uniqKey="Rana A" first="Anil" last="Rana">Anil Rana</name><affiliation wicri:level="2"><nlm:affiliation>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ja, William W" sort="Ja, William W" uniqKey="Ja W" first="William W" last="Ja">William W. Ja</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center on Aging, The Scripps Research Institute, 33458, Jupiter, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center on Aging, The Scripps Research Institute, 33458, Jupiter, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Clark, Rebecca I" sort="Clark, Rebecca I" uniqKey="Clark R" first="Rebecca I" last="Clark">Rebecca I. Clark</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences, Durham University, DH1 3LE, Durham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biosciences, Durham University, DH1 3LE, Durham</wicri:regionArea><wicri:noRegion>Durham</wicri:noRegion></affiliation></author><author><name sortKey="Walker, David W" sort="Walker, David W" uniqKey="Walker D" first="David W" last="Walker">David W. Walker</name><affiliation wicri:level="2"><nlm:affiliation>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California, USA. davidwalker@ucla.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Molecular Biology Institute, University of California, Los Angeles, 90095, Los Angeles, California, USA. davidwalker@ucla.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology Institute, University of California, Los Angeles, 90095, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31127145</idno><idno type="pmid">31127145</idno><idno type="doi">10.1038/s41598-019-44106-5</idno><idno type="pmc">PMC6534571</idno><idno type="wicri:Area/Main/Corpus">000267</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000267</idno><idno type="wicri:Area/Main/Curation">000267</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000267</idno><idno type="wicri:Area/Main/Exploration">000267</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila.</title><author><name sortKey="Schinaman, Joseph M" sort="Schinaman, Joseph M" uniqKey="Schinaman J" first="Joseph M" last="Schinaman">Joseph M. Schinaman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rana, Anil" sort="Rana, Anil" uniqKey="Rana A" first="Anil" last="Rana">Anil Rana</name><affiliation wicri:level="2"><nlm:affiliation>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ja, William W" sort="Ja, William W" uniqKey="Ja W" first="William W" last="Ja">William W. Ja</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Center on Aging, The Scripps Research Institute, 33458, Jupiter, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center on Aging, The Scripps Research Institute, 33458, Jupiter, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Clark, Rebecca I" sort="Clark, Rebecca I" uniqKey="Clark R" first="Rebecca I" last="Clark">Rebecca I. Clark</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences, Durham University, DH1 3LE, Durham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biosciences, Durham University, DH1 3LE, Durham</wicri:regionArea><wicri:noRegion>Durham</wicri:noRegion></affiliation></author><author><name sortKey="Walker, David W" sort="Walker, David W" uniqKey="Walker D" first="David W" last="Walker">David W. Walker</name><affiliation wicri:level="2"><nlm:affiliation>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California, USA. davidwalker@ucla.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Molecular Biology Institute, University of California, Los Angeles, 90095, Los Angeles, California, USA. davidwalker@ucla.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology Institute, University of California, Los Angeles, 90095, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Animals, Genetically Modified (MeSH)</term><term>Autophagy (drug effects)</term><term>Autophagy (genetics)</term><term>Autophagy-Related Protein-1 Homolog (genetics)</term><term>Drosophila (drug effects)</term><term>Drosophila (microbiology)</term><term>Drosophila (physiology)</term><term>Drosophila Proteins (genetics)</term><term>Female (MeSH)</term><term>Gastrointestinal Microbiome (drug effects)</term><term>Gene Knockdown Techniques (MeSH)</term><term>Germ-Free Life (MeSH)</term><term>Intestinal Mucosa (drug effects)</term><term>Intestinal Mucosa (metabolism)</term><term>Intestinal Mucosa (microbiology)</term><term>Longevity (drug effects)</term><term>Male (MeSH)</term><term>Models, Animal (MeSH)</term><term>Permeability (drug effects)</term><term>Proteostasis (drug effects)</term><term>Proteostasis (genetics)</term><term>RNA Interference (MeSH)</term><term>Sirolimus (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animal génétiquement modifié (MeSH)</term><term>Animaux (MeSH)</term><term>Autophagie (effets des médicaments et des substances chimiques)</term><term>Autophagie (génétique)</term><term>Axénie (MeSH)</term><term>Drosophila (effets des médicaments et des substances chimiques)</term><term>Drosophila (microbiologie)</term><term>Drosophila (physiologie)</term><term>Femelle (MeSH)</term><term>Homologue de la protéine-1 associée à l'autophagie (génétique)</term><term>Homéostasie protéique (effets des médicaments et des substances chimiques)</term><term>Homéostasie protéique (génétique)</term><term>Interférence par ARN (MeSH)</term><term>Longévité (effets des médicaments et des substances chimiques)</term><term>Microbiome gastro-intestinal (effets des médicaments et des substances chimiques)</term><term>Modèles animaux (MeSH)</term><term>Muqueuse intestinale (effets des médicaments et des substances chimiques)</term><term>Muqueuse intestinale (microbiologie)</term><term>Muqueuse intestinale (métabolisme)</term><term>Mâle (MeSH)</term><term>Perméabilité (effets des médicaments et des substances chimiques)</term><term>Protéines de Drosophila (génétique)</term><term>Sirolimus (pharmacologie)</term><term>Techniques de knock-down de gènes (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Autophagy-Related Protein-1 Homolog</term><term>Drosophila Proteins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term><term>Drosophila</term><term>Gastrointestinal Microbiome</term><term>Intestinal Mucosa</term><term>Longevity</term><term>Permeability</term><term>Proteostasis</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Autophagie</term><term>Drosophila</term><term>Homéostasie protéique</term><term>Longévité</term><term>Microbiome gastro-intestinal</term><term>Muqueuse intestinale</term><term>Perméabilité</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Autophagy</term><term>Proteostasis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Autophagie</term><term>Homologue de la protéine-1 associée à l'autophagie</term><term>Homéostasie protéique</term><term>Protéines de Drosophila</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Intestinal Mucosa</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Drosophila</term><term>Muqueuse intestinale</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Drosophila</term><term>Intestinal Mucosa</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Muqueuse intestinale</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Sirolimus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Drosophila</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Drosophila</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Genetically Modified</term><term>Female</term><term>Gene Knockdown Techniques</term><term>Germ-Free Life</term><term>Male</term><term>Models, Animal</term><term>RNA Interference</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animal génétiquement modifié</term><term>Animaux</term><term>Axénie</term><term>Femelle</term><term>Interférence par ARN</term><term>Modèles animaux</term><term>Mâle</term><term>Techniques de knock-down de gènes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The FDA approved drug rapamycin can prolong lifespan in diverse species and delay the onset of age-related disease in mammals. However, a number of fundamental questions remain unanswered regarding the mechanisms by which rapamycin modulates age-related pathophysiology and lifespan. Alterations in the gut microbiota can impact host physiology, metabolism and lifespan. While recent studies have shown that rapamycin treatment alters the gut microbiota in aged animals, the causal relationships between rapamycin treatment, microbiota dynamics and aging are not known. Here, using Drosophila as a model organism, we show that rapamycin-mediated alterations in microbiota dynamics in aged flies are associated with improved markers of intestinal and muscle aging. Critically, however, we show that the beneficial effects of rapamycin treatment on tissue aging and lifespan are not dependent upon the microbiota. Indeed, germ-free flies show delayed onset of intestinal barrier dysfunction, improved proteostasis in aged muscles and a significant lifespan extension upon rapamycin treatment. In contrast, genetic inhibition of autophagy impairs the ability of rapamycin to mediate improved gut health and proteostasis during aging. Our results indicate that rapamycin-mediated modulation of the microbiota in aged animals is not causally required to slow tissue and organismal aging.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31127145</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>20</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>20</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>05</Month><Day>24</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila.</ArticleTitle><Pagination><MedlinePgn>7824</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41598-019-44106-5</ELocationID><Abstract><AbstractText>The FDA approved drug rapamycin can prolong lifespan in diverse species and delay the onset of age-related disease in mammals. However, a number of fundamental questions remain unanswered regarding the mechanisms by which rapamycin modulates age-related pathophysiology and lifespan. Alterations in the gut microbiota can impact host physiology, metabolism and lifespan. While recent studies have shown that rapamycin treatment alters the gut microbiota in aged animals, the causal relationships between rapamycin treatment, microbiota dynamics and aging are not known. Here, using Drosophila as a model organism, we show that rapamycin-mediated alterations in microbiota dynamics in aged flies are associated with improved markers of intestinal and muscle aging. Critically, however, we show that the beneficial effects of rapamycin treatment on tissue aging and lifespan are not dependent upon the microbiota. Indeed, germ-free flies show delayed onset of intestinal barrier dysfunction, improved proteostasis in aged muscles and a significant lifespan extension upon rapamycin treatment. In contrast, genetic inhibition of autophagy impairs the ability of rapamycin to mediate improved gut health and proteostasis during aging. Our results indicate that rapamycin-mediated modulation of the microbiota in aged animals is not causally required to slow tissue and organismal aging.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schinaman</LastName><ForeName>Joseph M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rana</LastName><ForeName>Anil</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ja</LastName><ForeName>William W</ForeName><Initials>WW</Initials><AffiliationInfo><Affiliation>Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center on Aging, The Scripps Research Institute, 33458, Jupiter, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>Rebecca I</ForeName><Initials>RI</Initials><AffiliationInfo><Affiliation>Department of Biosciences, Durham University, DH1 3LE, Durham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walker</LastName><ForeName>David W</ForeName><Initials>DW</Initials><AffiliationInfo><Affiliation>Department of Integrative Biology and Physiology, University of California, Los Angeles, 90095, Los Angeles, California, USA. davidwalker@ucla.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Molecular Biology Institute, University of California, Los Angeles, 90095, Los Angeles, California, USA. davidwalker@ucla.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P40 OD018537</GrantID><Acronym>OD</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG049157</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG037514</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG040288</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>05</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Sci Rep</MedlineTA><NlmUniqueID>101563288</NlmUniqueID><ISSNLinking>2045-2322</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029721">Drosophila Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="C518074">Atg1 protein, Drosophila</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D000071189">Autophagy-Related Protein-1 Homolog</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D030801" MajorTopicYN="N">Animals, Genetically Modified</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000071189" MajorTopicYN="N">Autophagy-Related Protein-1 Homolog</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004330" MajorTopicYN="N">Drosophila</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029721" MajorTopicYN="N">Drosophila Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000069196" MajorTopicYN="N">Gastrointestinal Microbiome</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055785" MajorTopicYN="N">Gene Knockdown Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005856" MajorTopicYN="N">Germ-Free Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007413" MajorTopicYN="N">Intestinal Mucosa</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008136" MajorTopicYN="N">Longevity</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023421" MajorTopicYN="N">Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010539" MajorTopicYN="N">Permeability</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000074702" MajorTopicYN="N">Proteostasis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D034622" MajorTopicYN="N">RNA Interference</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>05</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>5</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>5</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31127145</ArticleId><ArticleId IdType="doi">10.1038/s41598-019-44106-5</ArticleId><ArticleId IdType="pii">10.1038/s41598-019-44106-5</ArticleId><ArticleId IdType="pmc">PMC6534571</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Californie</li><li>Floride</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Schinaman, Joseph M" sort="Schinaman, Joseph M" uniqKey="Schinaman J" first="Joseph M" last="Schinaman">Joseph M. Schinaman</name></region><name sortKey="Ja, William W" sort="Ja, William W" uniqKey="Ja W" first="William W" last="Ja">William W. Ja</name><name sortKey="Ja, William W" sort="Ja, William W" uniqKey="Ja W" first="William W" last="Ja">William W. Ja</name><name sortKey="Rana, Anil" sort="Rana, Anil" uniqKey="Rana A" first="Anil" last="Rana">Anil Rana</name><name sortKey="Walker, David W" sort="Walker, David W" uniqKey="Walker D" first="David W" last="Walker">David W. Walker</name><name sortKey="Walker, David W" sort="Walker, David W" uniqKey="Walker D" first="David W" last="Walker">David W. Walker</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Clark, Rebecca I" sort="Clark, Rebecca I" uniqKey="Clark R" first="Rebecca I" last="Clark">Rebecca I. Clark</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000254 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000254 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:31127145
|texte= Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31127145" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |